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Communication | Regular issue | Vol 31, No. 12, 1990, pp.2099-2102
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5592
Synthesis of a Thiomuscarone Analog

Gideon Shapiro* and Yair Lavi

*Preclinical Research, SANDOZ Pharma Ltd., CH-4002 Basle, Switzerland

Abstract

A novel synthesis of the thiomuscarone analog, 1-thia-2,8-dimethyl-3-oxo-8-azaspiro[4.5]decane (4) has been achieved. Other thiolan-3-ones which are highly substituted in the 5-position should be available by this method which provides and alternative to the classical Michael reaction-Dieckmann sequence.