Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 31, No. 12, 1990, pp.2099-2102
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5592
Synthesis of a Thiomuscarone Analog

Gideon Shapiro* and Yair Lavi

*Preclinical Research, SANDOZ Pharma Ltd., CH-4002 Basle, Switzerland


A novel synthesis of the thiomuscarone analog, 1-thia-2,8-dimethyl-3-oxo-8-azaspiro[4.5]decane (4) has been achieved. Other thiolan-3-ones which are highly substituted in the 5-position should be available by this method which provides and alternative to the classical Michael reaction-Dieckmann sequence.