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Paper | Regular issue | Vol 32, No. 6, 1991, pp.1081-1088
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5571
Synthesis of Novel 5-Mercapto-s-triazolo[3,4-c]-as-triazino[5,6-b]indoles and Their Mannich Bases

B. Shivarama Holla* and K. Venkatramana Udupa

*Department of P. G. Studies and Research in Chemistry, Mangalore University, Mangalagangothri, 574 199(DK), Karnataka Statte, India


Reaction of as-triazino[5,6-b]indol-3-ylhydrazines with carbon disulphide in the presence of methanolic potassium hydroxide gave the title compounds through angular cyclization. On subjecting the title compounds to Mannich reaction, the NH of the triazole ring underwent aminomethylation reaction. This is further confirmed by chemical routes and by recording the uv spectra of linearly and angularly cyclized products. Structures of all the newly synthesized compounds are established on the basis of elemental analysis, 1H nmr and mass spectral data. Few selected compounds are screened for their antiviral and antibacterial properties.