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■ 2,4,6-Tripyridino-1,3,5-triazine Trichloride, a New and Mild Esterification Agent for Preparation of Penicillin Esters

Masayuki Murakami,* Makoto Hajima, Fumitaka Takami, and Mitsuru Yoshioka

*Shionogi Research Laboratories, Shionogi & Co. Ltd., Fukushima-ku, Osaka 553-0002, Japan

Abstract

Cyanuric chloride reacted with 3 molar equivalents of pyridine to give 2,4,6-tripyridino-1,3,5-triazine trichloride, which was found to condense penicillines with alcohols under mild conditions ot afford penicillin esters in good yields. Application to preparation of cephalosporin esters also is discussed.