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Paper | Regular issue | Vol 31, No. 11, 1990, pp.2055-2064
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5565
2,4,6-Tripyridino-1,3,5-triazine Trichloride, a New and Mild Esterification Agent for Preparation of Penicillin Esters

Masayuki Murakami,* Makoto Hajima, Fumitaka Takami, and Mitsuru Yoshioka

*Shionogi Research Laboratories, Shionogi & Co. Ltd., Fukushima-ku, Osaka 553-0002, Japan


Cyanuric chloride reacted with 3 molar equivalents of pyridine to give 2,4,6-tripyridino-1,3,5-triazine trichloride, which was found to condense penicillines with alcohols under mild conditions ot afford penicillin esters in good yields. Application to preparation of cephalosporin esters also is discussed.