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Paper | Regular issue | Vol 31, No. 12, 1990, pp.2153-2161
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5554
The Hantzsch Synthesis with 6-Aminouracils: One Step Synthesis of Pyrido[2,3-d]pyrimidines

Masahiro Kajino* and Kanji Meguro

*Chemistry Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd., 17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan


A one-step synthesis of new pyrido[2,3-d]pyrimidine derivatives (III) was achieved through the Hantzsch synthesis using 6-aminouracils (I) as enamine nucleophiles.