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Communication | Regular issue | Vol 31, No. 11, 1990, pp.1903-1906
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5527
Structure and Stereochemistry of Pseudolarolide-I, a Novel Cytotoxic Peroxytriterpene Dilactone from Pseudolarix kaempferi

Guo-Fu Chen, Zhu-Lian Li,* Cheng-Min Tang, Xiang He, Ke Chen, De-Ji Pan, Chang-Qi Hu, Donald R. McPhail, Andrew T. McPhail,* and Kuo-Hsiung Lee*

*Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, U.S.A.


A novel cytotoxic peroxytriterpene dilactone, pseudolarolide I, has been isolated from the seeds of Pseudolarix kaempferi, and its structure and stereochemistry have been established from spectral data in conjunction with a single-crystal X-ray analysis.