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Paper | Regular issue | Vol 31, No. 11, 1990, pp.1967-1974
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5493
■ Pyridazine Derivatives, IX. Synthesis of 2H-Pyridazin-3-ones with Aroylpiperazinyl Groups

Enrique Ravina,* Carmen Teran, Lourdes Santana, Neftali Garcia, and Isabel Estevez

*Department of Organic Chemistry, Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago, 15706 Santiago de Compostela, Spain

Abstract

Several 2H-pyridazin-3-ones with phenyl- or 2-furoylpiperazinyl group, have been prepared. 6-Phenyl-5-(N4-aroyl-N1-piperazinyl)-2H-pyridazine-3-ones were obtained by nucleophilic substitution of the chlorine atom of 6-phenyl-5-chloro-2H-pyridazin-3-one or alternatively, by aroylation of N1-piperazinyl-2H-pyridazin-3-one. Also, 6-phenyl-5-(N4-aroyl-N1-piperazinylmethyl)-2H-pyridazin-3-ones were prepared by displacement of the bromine in 6-phenyl-5-bromomethyl-2H-pyridazin-3-one.