Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 31, No. 7, 1990, pp.1325-1331
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5413
Deoxygenative 2-Alkoxylation of Quinoline 1-Oxide

Mitsuo Hayashida, Haruyoshi Honda, and Masatomo Hamana*

*Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812, Japan


Treatment of quinoline 1-oxide (1) with ethyl chloroformate or tosyl chloride and triethylamine in some lower alcohols affords the corresponding 2-alkoxyquinolines (2a-f) in generally satisfactory yields. Reactions of 2-methylpyridine and 2-methylquinoline 1-oxides lead to the corresponding 2-ethoxycarbonyloxymethyl (3 and 5) and 2-ethoxymethyl derivatives (4 and 6).