Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 31, No. 6, 1990, pp.1011-1016
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5396
■ Acid Degradation Products of Qinghaosu and Their Structure-Activity Relationships

Yasuhiro Imakura,* Katsutoshi Hachiya, Tomomi Ikemoto, Shinsuke Yamashita, Masaru Kihara, Shigeru Kobayashi, Tetsuro Shingu, Wilbur K. Milhous, and Kuo-Hsiung Lee

*Faculty of Sciences, Naruto University of Education, Takashima, Naruto-shi, Tokushima 772- , Japan

Abstract

Treatment of qinghaosu (1) with acid yielded 1’,2’,4’-trioxanes (5 and 8), endoperoxides (6 and 9), and diketones (7 and 10). Structures of 5, 6, 7, 8, 9, and 10 were assigned based on their physical and spectral data. Structure-activity correlation among these compounds indicated the steric requirement of the 1’,2’,4’-trioxane ring system as found in 1 for potent antimalarial activity.