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Paper | Regular issue | Vol 31, No. 7, 1990, pp.1291-1300
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5391
Polycondensed Heterocycles. V. Synthesis of 5H,11H-Pyrrolo[2,1-c][1,4]benzothiazepine

Antonio Garofalo, Vito Nacci,* Federico Corelli, and Giuseppe Campiani

*Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Banchi di Sotto 55, 53100 Siena, Italy

Abstract

The 5H,11H-pyrrolo[2,1-c][1,4]benzothiazepine ring system has been prepared by two synthetic pathways, involving the intramolecular nucleophilic displacement on 1-(2-fluoreobenzyl)-2-mercaptomethylpyrrole or the Pummerer rearrangement of 1-(2-ethoxycarbonylmethylsulfinylbenzyl)pyrrole followed by in situ cyclization, respectively.