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Communication | Regular issue | Vol 31, No. 6, 1990, pp.987-991
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5374
Novel Bromolactonization Using a Dimethyl Sulfoxide-Trimethylsilyl Bromide-Amine System; Unusual cis-Addition of trans-6-Substituted 3-Cyclohexene-1-carboxylic Acids

Chuzo Iwata,* Akira Tanaka, Hiroaki Minuzo, and Kazuyki Miyashita

*Faculty of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka 565, Japan

Abstract

A novel method for bromolactonization using a dimethyl sulfoxide-trimethylsilyl bromide-amine system and first example for halolactonization in the mode of cis-addition are described.