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■ Synthesis of N,N’-[Bis(adenosin-8-yl)]diaminoalkanes and -piperazine

Yuris A. Maurinsh, Keiko Sujino, Hideo Togo, and Masataka Yokoyama*

*Department of Chemistry, Faculty of Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

Abstract

Several N,N’-[bis(adenosin-8-yl)]diaminoalkanes and -piperazine were prepared by the following procedure; 8-bromoadenosine reacted with diamines to give the corresponding N-(adenosin-8-yl)diaminoalkanes and -piperazine, which were then converted into the title compounds by treatment with another 8-bromoadenosine.