Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 31, No. 5, 1990, pp.791-795
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5344
Novel 2-Methyl-1-oxacephalosporins 1. Synthesis of 2-Methyl-3-nor-1-oxacephem Nucleus

Tsuneo Okonogi,* Seiji Shibahara, Yasushi Murai, Sigeharu Inouye, Shinichi Kondo, and Burton G. Christensen

*Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan

Abstract

The 2α- and 2β-methyl-1-oxacephems were synthesized stereoselectively starting from (3R,4S)-oxazolinoazetidinone by reaction with chiral alcohols followed by intramolecular carbene insertion of α-diazo-β-keto intermediates.