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Paper | Special issue | Vol 30, No. 2, 1990, pp.971-982
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S96
Oxaziridines and Nitrones as Potential Inhibitors of Bacterial D,D-Peptidases

Jacqueline Marchand-Brynaert, Zoubida Bounkhala-Khrouz, Huguette Vanlierde, and Léon Ghosez*

*Laboratoire de Chimie Organique de Synthèse, Université Catholique de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium

Abstract

Novel functionalized oxaziridines and nitrones have been prepared and examined as potential irreversible inhibitors of bacterial PBPs. N-(β-Hydroxycarbonyl)ethyloxaziridines were found to undergo a fast isomerisation in protic solvent to yield the corresponding nitrones.