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Paper | Special issue | Vol 30, No. 2, 1990, pp.963-969
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S95
The Synthesis of 8-Amino-6-N-methyl-1,2,3,5,6,7-hexaazaacenaphthylene

Andrew Van Sickle, Andrew M. Kawasaki, and Leroy B. Townsend*

*Department of Medical Chemistry, College of Pharmacy, University of Michigan , 930 North University, Ann Arbor, MI 48109-1055, U.S.A.


The protected tricyclic heterocycle 8-amino-6-N-methyl-2-(tetrahydropyran-2-yl)-1,2,3,5,6,7-hexaazaacenaphthylene (11) was prepared from3-cyano-4,6-bis-methylthiopyrazolo[3,4-d]pyrimidine (5) in a six-step reaction sequence. Treatment of 11 with hydrogen chloride gas under anhydrous conditions has afforded 8-amino-6-N-methyl-1,2,3,5,6,7-hexaazaacenaphthylene (4) in a moderate yield.