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Paper | Special issue | Vol 30, No. 1, 1990, pp.415-425
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S9
The Synthesis of 9-(1-Azetidinyl)-1,2,3,4-tetrahydroacridine

Eric. T. Michalson, Stan D’Andrea, Jeremiah P. Freeman, and Jacob Szmuszkovicz*

*Department of Chemistry, University of Notre Dame, Notre Dame, IN 46556, U.S.A.

Abstract

Synthesis of analogue (2) of tacrine is described in which the primary amino group is replaced by the azetidine moiety. The synthesis was accomplished in two steps from the acridinone derivative 10. This involved conversion of 10 to triflate 11, followed by treatment with azetidine to give the target compound 2.