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Paper | Special issue | Vol 30, No. 1, 1990, pp.607-616
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S73
Two New Fungal Azaphilones from Talaromyces luteus, with Monoamine Oxidase Inhibitory Effect

Haruhiro Fujimoto, Takanao Matsudo, Akira Yamaguchi, and Mikio Yamazaki*

*Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

Abstract

Two new compounds with monoamine oxidase (MAO) inhibitory effect isolated from an ascomycete, Talaromyces luteus, have been deduced to be azaphilone compounds, (8R)-7-deacetyl-O8,8-dihydro-7-epi-sclerotiorin and its (Z)-isomer at position 11 from their chemical and spectral data.