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Communication | Special issue | Vol 30, No. 1, 1990, pp.363-366
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S69
An Efficient Synthesis of Natural (+)-Neoisostegane Using Asymmetric Hydrogenation Catalyzed by a Chiral Bisphosphine-Rhodium(I) Complex

Toshiaki Morimoto, Mitsuo Chiba, and Kazuo Achiwa*

*Schol of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan

Abstract

(+)-Neoisostegane, a natural lignan lactone was synthesized by utilizing a catalytic asymmetric hydrogenation of α-veratrylidenesuccinic acid half-ester with a (S,S)-MOD-DIOP-rhodium(I) as a key step, and the absolute configuration was determined to be (M,6R,7R).