Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 30, No. 2, 1990, pp.863-869
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S68
The Synthesis of Carbapenem and Carbacephem Derivatives by a Combination of 4CC with the Chemistry of Oxazoles and N-Boc-carbonamides

Gebhard Neyer, Josef Achatz, Bernhard Danzer, and Ivar Ugi*

*Organisch-Chemisches Institut der Techmisches, Universität München, Münvhen, D-8046 Garching, Germany


A synthetic approach to carbapenem and carbacephem derivatives is described. It is based on the formation of the N-carboxymethyl-β-lactam system by a four component condensation, the cleavage of a carbonamide via the N-Boc-carbonamides and esters, and the masking of a carboxyl group as its 4,5-diphenyloxazolyl derivative that is convertible to an N,N-dibenzoylamide by photooxidation.