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Communication | Special issue | Vol 30, No. 1, 1990, pp.339-340
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S61
An Asymmetric Synthesis of the Takano Lactone. A Formal Synthesis of 9-(—)-Eburnamine

A. I. Meyers,* Jeffery Romine, and Albert J. Robichaud

*Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, U.S.A.

Abstract

The lactone 2 known as a precursor to the alkaloid eburnamine 1 has been prepared via bicyclic lactam 4 in 4 steps in 35% overall yield and >99% enantiomeric excess.