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Communication | Special issue | Vol 30, No. 2, 1990, pp.745-748
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S48
Biocatalytic Preparation of Chiral β-Hydroxy Esters Substituted with Heteroring at γ-position

Katsuyuki Kurumaya, Kazuhiko Takatori, Rieko Isii, and Masahiro Kajiwara*

*Department of Medicinal Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

Asymmetric reduction were examined of β-keto esters substituted with dithiane ring at γ-position with microorganism and gave the alcohol with high optical purity. Also the chiral carbinol with furan ring was obtained by the hydrolysis of the corresponding acetate with lipase or baker’s yeast.