HETEROCYCLES

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■ Highly Accelerated Reactions in a Microwave Ovem: Synthesis of Heterocycles

Ajay K. Bose,* Maghar S. Manhas, Malay Ghosh, Vegesna S. Raju, Keiko Tabei, and Zofia Urbancyk-Lipkowska

*Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Castle Point on the Hudson, Hoboken, NJ 07030, U.S.A.

Abstract

Efficient synthesis of a wide variety of heterocycles on 0.1 to 200 g scale was conducted in organic solvents in a commercial microwave oven in a few minutes at a low energy level. Erlenmeyer flasks were adequate reaction vessels since neither high pressure nor high temperature were involved. Fast monitoring of synthetic reactions was achieved by tlc separation and transfer of tlc spot material directly to a solids probe of a chemical ionization mass spectrometer. Microwave Oven-induced Reaction Enhancement (MORE) chemistry is not due to thermolysis: one reaction was conducted successfully in a reaction vial encased in a block of ice.