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Communication | Special issue | Vol 30, No. 1, 1990, pp.299-302
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S41
A Novel Synthesis of Cyclohexylnorstatine Isopropyl Ester, the C-Terminal Component of a Renin Inhibitor

Yoshio Ito, Tetsuhide Kamijo, Hiromu Harada, and Shiro Terashima*

*Sagami Central Research Center, Hayakawa, Ayase, Kanagawa 252-1193, Japan


The title compounds was produced diastereoselectively in recemic and optically active forms by employing the [2+2] cycloaddition reaction of an imine with benzyloxyketene followed by acidic alcoholysis of the formed 3,4-cis-disubstituted β-lactam with isopropanol.