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Paper | Special issue | Vol 30, No. 1, 1990, pp.507-515
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S32
Novel Epidithiodioxopiperazines, Emethallicins E and F, from Emericella heterothallica

Nobuo Kawahara, Koohei Nozawa, Mikio Yamazaki, Shoichi Nakajima, and Ken-ichi Kawai*

*Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

Novel epidithiodioxopiperazines, emethallicins E (1) and F (2), were isolated from the mycelial extract of Emericella heterothallica (mating type A). The structures of emethallicins E (1) and F (2) were determined on the basis of spectroscopic and chemical investigation, compared with other emethallicins isolated from the above fungus and the other strain. Emethallicin E (1) is an epidithiodioxopiperazine having a novel carbon skeleton related to emethallicins A (3), B (4), C (5), and D (6), whereas emethallicin F (2) and D (6). Emethallicins E (1) and F (2) have a potent inhibitory activity for histamine release as well as the other emethallicins.