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Paper | Special issue | Vol 30, No. 1, 1990, pp.471-486
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S23
Synthesis of 2-Substituted Drivatives of Diltiazem

Masamichi Morimoto, Harumichi Kohno, Kosuke Yasuda, Tadamasa Date, Norio Takamura,* and Shigehiko Sugasawa

*Discovery Research Laboratory, Tanabe Seiyaka Co. Ltd., 2-2-50, Kawagishi, Toddda, Saitama 335-8505, Japan


Titled compounds, 2a,b,c,d and e, were efficiently synthesized from 3-acetoxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (4) through alkylation at the C2-position followed by stereoselective reduction of the C3-carbonyl group.