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Paper | Special issue | Vol 30, No. 1, 1990, pp.463-469
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S22
Synthesis of N, N’-Bis(aryl)-N-(2-thiazolin-2-yl)thioureas

M. Avalos González, R. Babiano Caballero, P. Cintas Moreno,* J. L. Jiménez Requejo, and J. C. Palacios Albarrán

*Department of Organic Chemistry, Facultad de Veterinard, University of Extremadura, 06071-Badajoz, Spain


The reaction of arylisothiocyanates with 2-chloroethylamine in pyridine led to the formation of complex N,N’-bis(aryl)-N-(2-thiazolin-2-yl)thioureas (1-3). These compounds and the mixed thioureas or ureas 8-11, show a strong chelated structure due to the presence of an intramolecular hydrogen bond.