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Paper | Special issue | Vol 30, No. 1, 1990, pp.435-440
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S14
Purines. IX. Reaction of 9-Phenyl-9H-purine-2-carbonitriles with Grignard Reagents

Ken-ichi Tanji* and Takeo Higashino

*Laboratory of Organic Chemistry, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan

Abstract

The palladium-catalyzed cross-coupling reaction of 2- and 6-chloro-9-phenyl-9H-purines with potassium cyanide proceeded to give 9-phenyl-9H-purine-2- (3a-c) and -6-carbonitriles (4a-c). The conversion of the cyano group at the 2-position into the corresponding acyl group was achieved by treatment of 3a,b with Grignard reagents.