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Paper | Special issue | Vol 30, No. 2, 1990, pp.1141-1153
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S113
Nucleotides, XXXIII: Synthesis and Properties of Inosinate Trimer I2’p5’I2’p5’I and Inosinate Tetramer I2’p5’I2’p5’I2’p5’I

Ramamurthy Charubana and Wolfgang Pfleiderer*

*Fakultät für Chemie, Universität Konstanz, Posttach 5560, D-7750 Konstantz, Germany


The chemical synthesis of 2’-5’ inosinate trimer and tetramer was achieved by the phosphotriester method using the 2-(p-nitrophenyl)ethyl group for phosphate protection. The sugar hydroxyl groups have either been protected by the (tert-butyl)-dimethylsilyl or the benzoyl group. Final deprotection to the unblocked oligomers was achieved in over 85% yield. The inosinate oligomers show some antiviral activity against TMV.