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Paper | Special issue | Vol 30, No. 1, 1990, pp.427-433
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S11
A Facile Synthesis of 3-(2-Amino-4-ethoxyphenyl)pyridine

Kimiyuki Shibuya, Hiromichi Shigyo, and Tomio Ohta*

*Tokyo Research Laboratories, Kowa Co., Ltd., 2-17-43, Noguchi-cho, Higashimurayama 189, Japan


A facile and efficient synthesis of 3-(2-amino-4-ethoxyphenyl)pyridine (6), a key intermediate of the antiarrythmic agent, has been developed starting from 3-bromopyridine (2) by the benzyne reaction using sodium benzylamide as the key step.