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Communication | Regular issue | Vol 31, No. 2, 1990, pp.223-227
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5270
Development of a Hydrazine-mediated System for the Reductive Activation of Mitomycin C

David J. Russell and Harold Kohn*

*Department of Chemistry, University of Houston, Houston, TX 77204-5641, U.S.A.


The reactivity of mitomycin C (1) with hydrazines (2) has been examined. Monoarylhydrazines have been shown to efficiently reduce 1 leading to the activation of both proposed DNA binding sites (C-1 and C-10) within the drug.