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Paper | Regular issue | Vol 31, No. 2, 1990, pp.327-339
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5244
The Use of Phosphonitrilic Dichloride Cyclic Trimer in Oligopeptide Synthesis. Synthesis of Isoxazolyl-Prodrugs of Netropsin and Distamycin

Erik J. Verner, Bradford J. Oliver, Ludwig Schlicksupp, and Nicholas R. Natale*

*Department of Chemistry, University of Idaho, 301 Renfrew Hall, Moscow, ID 83844-2343, U.S.A.

Abstract

Phosphonitrilic dichloride cyclic trimer has been found to be an effective activating agent for the synthesis of oligopeptides containing N-terminal isoxazole-4-carboxamide groups.