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Paper | Regular issue | Vol 31, No. 7, 1990, pp.1245-1250
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5232
Studies on Intramolecular Mannich Reaction of (S)-2-(α-Hydroxyethyl)benzimidazole. Synthesis of (1S)-4-Aryl-4,5-dihydro-1-methyl-1H,3H-[1,3,5]oxadiazepino[5,6-a]benzimidazoles — A New Class of Heterocyclic Compounds

Shaheen A. Hussain,* Tahira B. Sarfaraz, Naheed Sultana, Najma Murtaza, and Izhar H. Qureshi

*Pharmaceutical and Fine Chemical Research Centre, P.C.S.I.R. Laboratories, Karachi-75280, Pakistan

Abstract

The intramolecular Mannich reaction of (S)-2-(α-hydroxyethyl)benzimidazole with primary aromatic amines IIa-g and formaldehyde has been shown to furnish a new class of heterocyclic compounds: (1S)-4-aryl-4,5-dihydro-1-methyl-1H,3H-[1,3,5]oxadiazepino[5,6-a]benzimidazoles IIIa-g. the antibacetrial activity of these compounds has also been evaluated.