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Paper | Regular issue | Vol 31, No. 1, 1990, pp.153-161
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5222
Pollycyclic N-Hetero Compounds. XXXI. Synthesis and Anti-platelet Aggregation Activity of 4-Substituted 5,6-Dihydrobenzo[h]quinazolines

Takashi Hirota,* Kenji Sasaki, Hiromi Ohtomo, Ayako Uehara, and Taiji Nakayama

*Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan


4-Substituted 5,6-dihydrobenzo[h]quinazolines (IV) were synthesized by the reaction of 4-chloro-5,6-dihydrobenzo[h]quinazoline (II) with amines (III) and their inhibitory activity against platelet aggregation was investigated.