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Communication | Regular issue | Vol 31, No. 1, 1990, pp.9-12
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5202
New and Efficient Synthesis of 5,6,7,8-Tetrahydroindolizidines. Application to the Synthesis of Pharmacologically Relevant Chiral Aminoderivatives from L-Asparagine

Peter Gmeiner* and Holger Lerche

*Institut für Pharmazie und Lebensmittelchemie, Ludwig-Maximilins-Universität, Sophienstraße 10, 8000 München 2, Germany


A convenient and high yielding cyclization reaction of N-pyrrolylbutyl triflates is shown. The method is applied to afford the potential DA agonists 3, enantiomerically pure from L-aspargine.