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Communication | Regular issue | Vol 31, No. 1, 1990, pp.5-8
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5196
A Stereocontrolled Synthesis of the 16-Membered Ring Macrolide Aglycones, Niddanolide, Carbonolide B, and Platenonolide W1

Noriyuki Nakajima, Kouichi Uoto, and Osamu Yonemitsu*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060, Japan

Abstract

The aglycones of the 16-membered ring macrolide antibiotics, niddanolide, carbonolide B, and platenonolide W1, were synthesized via the Yamaguchi esterification of the C1-10 segment and the C11-C15 segment, prepared stereoselectively from n-glucosed, followed by an intramolecular Wittig-Horner type cyclization.