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Paper | Regular issue | Vol 29, No. 11, 1989, pp.2199-2207
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5161
A Novel Synthesis of 3-(2-Amino-4-ethoxyphenyl)pyridine

Kimiyuki Shibuya, Yoshio Takahashi, Hiromichi Shigyo, and Tomio Ohta*

*Tokyo Research Laboratories, Kowa Co., Ltd., 2-17-43, Noguchi-cho, Higashimurayama 189, Japan


A novel and efficient synthesis of 3-(2-amino-4-ethoxyphenyl)pyridine (2), a key intermediate of the antiarrhythmic agents, has been developed starting from p-cresol (3).