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Paper | Regular issue | Vol 31, No. 1, 1990, pp.109-114
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5150
Synthesis of 2-t-Butyl-5-hydroxypyrimidine via Hydrolysis of 2-t-Butyl-5-halopyrimidines

Richard Garth Pews*

*Organic Chemicals and Polymers Laboratry, Central Research, The Dow Chemical Company, Midland, Michigan 48674, U.S.A.


The hydrolysis of 2-t-butyl-5-halopyrimidine (halogen = bromine or chlorine) with sodium methoxide in methanol yields 2-t-butyl-5-hydroxypyrimidine. The side reaction product, 2-t-butylpyrimidine, is substantially reduced, especially in the case of the bromo derivative, with catalytic amounts of elemental sulfur.