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Paper | Regular issue | Vol 31, No. 1, 1990, pp.37-45
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5083
Synthesis of Methyl 4-(2,2-Dimethoxyethyl)-6-hydroxy-7-methoxyindole-2-carboxylate: A Potential Intermediate for the Synthesis of the Central and Right Parts of the Anticancer Antibiotic CC-1065

Luis Castedo, Carlos F. Marcos, María Ruiz, and Gabriel Tojo*

*Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, E-15706, Santiago de Compostela, Spain


We describe an efficient synthesis of methyl 4-(2,2-diemthoxyethyl)-6-hydroxy-7-methoxyindole-2-carboxylate (5), a key inermediate for the synthesis of the cetnral and right parts of the antitumor agent CC-1065 (1) and of the inhibitors of cyclic adenosine-3’,5’-monophosphate phosphodiesterase PDE-I (2) and PDE-II (3).