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Communication | Regular issue | Vol 29, No. 8, 1989, pp.1473-1476
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5064
A Concise Enantioselective Synthesis of Acromelic Acid B from (S)-O-Benzylglycidol

Seiichi Takano,* Shun’ichi Tomita, Yoshiharu Iwabuchi, and Kunio Ogasawara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


The potent neurotoxin, acromelic acid B, has been synthesized by an enantioselective route employing an intramolecular 1,3-dipolar cyclization as the key step.