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Paper | Regular issue | Vol 29, No. 10, 1989, pp.1907-1914
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5046
Synthesis of New s-Triazolo[4,3-b]pyridazines

Adbel Moneim El Massry and Adel Amer

*Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt

Abstract

The 2,3-dihydropyridazin-3-ones 9 were synthesized via functionalized pyruvic acids 7 with hydrazine hydrate. Transformation of 9 to s-triazolo[4,3-b]pyridazines 10a-c and 11a-c has been achieved through the 3-chloropyridazines 4 by treatment with semicarbazide aqd phenylacetylhydrazine, respectively.