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Paper | Regular issue | Vol 29, No. 9, 1989, pp.1773-1779
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5042
Addition of Arylzirconium Tributoxides to 17-Ketosteroids

Virendra Kumar* and Malcolm R. Bell

*Sterling Winthrop Pharmaceuticals Research Division, Rensselaer, New York, 12144, U.S.A.


Reaction of 17-oxoandrost-2,4-dieno[2,3-d]isoxazole 3 with arylzirconium tributoxides gives the corresponding C-17 aryl carbinols. Arylzirconium tributoxides are selective nucleophiles towards readily enolizable 17-ketosteroids and are less basic than lithium and Grignard reagents.