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Paper | Regular issue | Vol 29, No. 8, 1989, pp.1595-1600
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5023
New Synthetic Approach to Pyrazolo[3,4-d]pyridazin-7(6H)-one Ring System

Vittorio Dal Piaz,* Giovanna Ciciani, Maria Paola Giovannoni, and Giovanni Turco

*Dipartimento di Scienze Farmaceutiche, Università di Ferrara, via Fossato di Mortara 17, I-44100, Ferrara, Italy


Treatment of 2,6-disubstituted 5-acetyl-4-nitropyridazin-3(2H)-ones (2a-b) with hydrazine or substituted hydrazines in alcoholic medium gives rise in high yields to new 1H- and 2H-pyrazolo[3,4-d]pyridazin-7(6H)-ones (1a-f).