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Paper | Regular issue | Vol 29, No. 8, 1989, pp.1517-1528
Published online, 1st January, 1970
DOI: 10.3987/COM-89-4984
Synthesis and Cardiotonic Activity of 5-(2-Substituted Thiazol-4-yl)-2-pyridones and Thiazolo[4,5-f]quinolinones

Hiroshi Fukatsu,* Yoshiaki Kato, Satoshi Murase, and Susumu Nakagawa

*Okazaki Research Laboratories, Banyu Pharmaceutical Co., Ltd., 3-9-1, Kamimutuna, Okazaki, Aichi 444, Japan


A variety of 5-(2-substituted thiazol-4-yl)-2-pyridones and thiazolo[4,5-f]quinoliiones were synthesized and tested in vitro for cardiotonic activity. Several compounds of these series showed good positive inotropic activity.