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Paper | Regular issue | Vol 29, No. 7, 1989, pp.1317-1323
Published online, 1st January, 1970
DOI: 10.3987/COM-89-4977
Condensed Thienopyrimidines 5. Studies on the Thermal Cyclization of Various ortho-Formylthiophenecarbamates with Ethanolamine

Mitsuo Sugiyama, Toshiaki Sakamoto, and Hiroshi Fukumi*

*Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

Abstract

Condensatlo of various ortho-formylthiophenecarbamates with ethanolamine afforded angular annelated tricyclic oxazolothienopyrimidine derivatives, 2,3,6,9b-tetrahydro-5H-oxazolo [3,2-c] thieno [2,3-e]-, and [3,2-e] pyrimidin-5-ones (2), which have new heterocyclic ring systems. The reaction mechanism on the formation of 2 is discussed.