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Paper | Regular issue | Vol 29, No. 5, 1989, pp.979-983
Published online, 1st January, 1970
DOI: 10.3987/COM-89-4942
Substituted Spiro[pyrrolidine-5,2’-tricyclo[,7]decane] Derivatives

Christpher G. Acker, George B. Mullen, Lesley A. Radov, Laura A. Trusso, Dietgard K. Kamp, and Vassil St. Georgiev*

*Department of Chemistry and Pharmacology, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623, U.S.A.


The synthesis of a series of novel substituted spiro[pyrrolidine-5,2’-tricyclo[,7]decane] derivatives 5-13 is described. When tested in the carrageenin-induced rat paw edema assay, several analogues elicited anti-inflammatory activity.