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Paper | Regular issue | Vol 29, No. 8, 1989, pp.1477-1487
Published online, 1st January, 1970
DOI: 10.3987/COM-89-4933
Syntheses of Functionalized Derivatives of Quinazolines and 1,4-Bensodiazepines

Maurizio Anzini, Antonio Garofalo, and Salvatore Vomero*

*Dipartimento Farmaco Chimico Technlogico, Università degli Studi di Siena, Banchi di Sotto, 55 - 53100 Siena, Italy

Abstract

The 2-substituted 1,4-benzodiazepines (4 and 6) were synthesized. The reaction of 2-aminobenzophenone oximes with ethyl 4-chloroacetoacetate gave the 1,4-benzodiazepines (4) and the 1,2-dihydroquinazolines (5); the latter were treated with a base to result ring expansion giving the 1,4-benzodiazepines (6).