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Communication | Regular issue | Vol 29, No. 5, 1989, pp.853-856
Published online, 1st January, 1970
DOI: 10.3987/COM-89-4925
Ring Construction of Bicyclic-β-lactam by Use of Palladium Catalyzed Carbonylation

Miwako Mori,* Yukako Higuchi, Katsuji Kagechika, and Masakatsu Shibasaki*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan

Abstract

Palladium catalyzed carbonylation Into vlnyl halide 10 afforded carbacepham 11 in good yield. The introduction of methoxycarbonyl group at C-4 position of carbacepham was achieved by conversion of methoxy group introduced by anodic oxidation in MeCN-MeOH to carboxyl group.