Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 29, No. 7, 1989, pp.1275-1282
Published online, 1st January, 1970
DOI: 10.3987/COM-89-4922
Synthesis of 5β-Androsta-17β-(1’-oxocyclohex-2’-en-3’-yl)-3β,14β,diol-3-β-D-glucopyranoside, a Potent Cardiac Glucoside with High Safety Margin

Uttam K. Pati* and Karel Wiesner

*Natural Products Research Center, Department of Chemistry, University of New Brunswick, Bag Service #45222, Fredericton, New Brunswick, E3b 5A3, Canada

Abstract

Starting from testosterone 1, an efficient preparation of a cardioactive glucoside 13 with a modified 17β- functionality is described. The glucoside 13, in spite of no lactone group at the 17β- position, is found to be potent and showed a high margin of safety.