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Paper | Regular issue | Vol 29, No. 6, 1989, pp.1107-1118
Published online, 1st January, 1970
DOI: 10.3987/COM-89-4895
C(2)-Carboxy and Carboxymethyl Cephems

Douglas O. Spry,* Nancy J. Snyder, David A. Preston, and Chyun-Yen E. Wu

*Lilly Reserach Laboratories, Lilly Corporate Center, Eli Lilly & Company, Indianapolis, IN 46285-4813, U.S.A.

Abstract

A series of C(2)-substituted [methyl, carboxy and carboxymethyl] cephems have been prepared. Test data show a significant reduction in antiblotic activity. Penicillin binding protein (PBP) studies show a decreased affinity to essential PBP-3 in S. aureus X1.1 and E. coli K12. The effect is believed to be steric in nature.