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Paper | Regular issue | Vol 29, No. 4, 1989, pp.707-718
Published online, 1st January, 1970
DOI: 10.3987/COM-89-4820
Synthesis and Reactions of Isoquinoline Derivatives V. Synthesis and Reactions of 3-Chiloroisoquinoline-4-carboxylic Acids

Wilhelm Bartmann, Elmar Konz, and Wolfgang Rüger*

*Entwicklungsgruppe Synthese und SBU Antiinfektiva, Allgemeine Pharma Forschung, Hoechst AG, Postfach 800320, D-65926 Frankfurt, Main 80, Germany

Abstract

Derivatives of 3-chloroisoquinoline-4-carboxylic acid are easily accessible by potassium permanganate oxidation of the corresponding aldehydes. Conditions have been developed for selective reduction, substitution and decarboxylation reactions leading to 3-substituted isoquinoline derivatives with, interesting pharmacological properties.