Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 28, No. 1, 1989, pp.63-65
Published online, 1st January, 1970
DOI: 10.3987/COM-88-S24
Enantioselective Synthesis of Naturally Occurring (—)-Tylophorine by Way of an Asymmetric Intramolecular Double Michael Reaction

Masataka Ihara, Yoshinobu Takino, Keiichiro Fukumoto,* and Tetsuji Kametani

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


Treatment of the 8-phenylmenthyl α. β -unsaturated amide ester (3) with tert.-butyldimethylsilyl trifluoromethanesulfonate and triethylamine produced, with a complete diastereofacial selection, the indolizidines (4), which were converted into (-)-(R)-tylophorine (1).